Document Type : Mini-Review
Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Kurdistan, Iran Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran
High Performance Powertrain Materials Laboratory, School of Engineering, University of British Columbia – Okanagan, Kelowna, V1V 1V7, Canada
Self-assembled nanostructures can be created as the spontaneous organization of individual nanomaterials via entropy maximization (under suitable conditions) into ordered nanostructures by non-covalent interactions such as van der Waals and hydrophobic interactions. Nucleic acids, amino acids, and lipids are the main building blocks to producing natural self-aasembled nanostructures. For self-assembled nanocarriers as reversible organization, several advantages have been found including biocompatibility, biochemical diversity, and high loading efficiency for both hydrophilic and hydrophobic therapeutic agents, and ability to passive and active targeting. In the case of cancers, these benefits can improve formulations due to inactivation or eradication of various cancer cells. However, there are some limitations such as low stability in the physiological conditions for these formulations, which we have tried to address these issues.
- Targeting of anticancer drugs with low side effects is the critical factor for new effective formulations.
- Self-assembled nanostructures can be obtained as the spontaneous organization of individual nanomaterials via entropy maximization into ordered nanostructures.
- There are several benefits for self-assembled nanocarriers involving biocompatibility, biochemical diversity, ability to passive and active targeting, and high loading efficiency for both hydrophilic and hydrophobic therapeutic agents.
- Low stability is the major limitation of these formulations in physiological conditions, which can be modified by organic or inorganic stabilizers specifically polymers such as polyvinyl alcohol, polyethylene glycol succinate, polyvinyl pyrrolidone, and carboxymethylcellulose sodium.