Novel formulations of ellagic acid for the improvement of antimicrobial, antioxidant, anticancer, antidiabetic, and neuroprotective applications

Document Type : Mini-Review

Authors

1 Department of Biology, Faculty of Science, Khorramabad, Lorestan University, Lorestan, Iran

2 Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

10.22034/nmbj.2023.388479.1015

Abstract

The application of bioactive compounds in combination with conventional drugs can improve therapeutic activities. Various therapeutic activities involve antimicrobial, antioxidant, anticancer, antidiabetic, and neuroprotective properties for ellagic acid and its derivatives such as 3,3′-di-O-methyl ellagic acid. For example, ellagic acid has been proclaimed to be effective in the regression of various kinds of tumors, involving but not limited to lung cancer, colorectal carcinoma, esophageal cancer, metastatic melanoma, hepatocellular carcinoma, tongue cancer, breast cancer, bladder cancer, endometrial carcinoma, and prostate cancer. However, ellagic acid has a hydrophobic or lipophilic property that leads to low circulation in the reticuloendothelial system (RES) or bioavailability. This mini-review discusses various formulations of ellagic acid considering therapeutic activities based on their bulk and nano aspects.

Graphical Abstract

Novel formulations of ellagic acid for the improvement of antimicrobial, antioxidant, anticancer, antidiabetic, and neuroprotective applications

Highlights

  • Ellagic acid has hydrophobic or lipophilic properties as a significant limitation for clinical formulation.
  • Novel formulations in micro and nano scales can augment the therapeutic activity of ellagic acid.
  • Loading of the ellagic acid by apamin-functionalized emulsomes showed a significant apoptotic effect in breast cancer cells.

Keywords

Main Subjects

Rights and permissions

© 2023 by the NMB. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Nano Micro Biosystems
Volume 2, Issue 1
March 2023
Pages 31-35

Files

History

  • Receive Date: 05 March 2023
  • Revise Date: 01 April 2023
  • Accept Date: 01 April 2023

Share

How to cite

Statistics