Document Type : Mini-Review
Department of Biology, Faculty of Science, Khorramabad, Lorestan University, Lorestan, Iran
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
The application of bioactive compounds in combination with conventional drugs can improve therapeutic activities. Various therapeutic activities involve antimicrobial, antioxidant, anticancer, antidiabetic, and neuroprotective properties for ellagic acid and its derivatives such as 3,3′-di-O-methyl ellagic acid. For example, ellagic acid has been proclaimed to be effective in the regression of various kinds of tumors, involving but not limited to lung cancer, colorectal carcinoma, esophageal cancer, metastatic melanoma, hepatocellular carcinoma, tongue cancer, breast cancer, bladder cancer, endometrial carcinoma, and prostate cancer. However, ellagic acid has a hydrophobic or lipophilic property that leads to low circulation in the reticuloendothelial system (RES) or bioavailability. This mini-review discusses various formulations of ellagic acid considering therapeutic activities based on their bulk and nano aspects.
- Ellagic acid has hydrophobic or lipophilic properties as a significant limitation for clinical formulation.
- Novel formulations in micro and nano scales can augment the therapeutic activity of ellagic acid.
- Loading of the ellagic acid by apamin-functionalized emulsomes showed a significant apoptotic effect in breast cancer cells.