Anticancer, antimicrobial, cardioprotective, and neuroprotective activities of luteolin: A systematic-narrative mini-review

Document Type : Mini-Review

Authors

1 Department of Plant Production and Genetics, Faculty of Agriculture, Razi University, Kermanshah, Iran

2 Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Kurdistan, Iran

10.22034/nmbj.2023.403963.1022

Abstract

Luteolin is a flavone subclass of flavonoids usually available as glycosylated forms in plant species. The low aqueous solubility or bioavailability of this herbal compound is the dominant limitation for its clinical formulation. The benzylation of the hydroxy groups at 7-, 3′- and 4′- positions improves the oral bioavailability of this phytoactive compound. We systematically searched the biomedical database of PubMed to categorize related studies about luteolin with antimicrobial, anticancer, cardio protective, and neuroprotective activities from 1946 to May 2023. Literatures were analyzed based on data extracted from PubMed, an online, researchable database. The minimum and maximum number of publications was indicated respectively for antifungal and anticancer activities of luteolin in 2021-2022. In the case of cancers, breast and lung cancers have demonstrated a higher number of publications compared to prostate and uterine cancers. Moreover, luteolin has been evaluated significantly for Alzheimer’s disease and hypertension.

Graphical Abstract

Anticancer, antimicrobial, cardioprotective, and neuroprotective activities of luteolin: A systematic-narrative mini-review

Highlights

  • Breast and lung cancers have shown a higher number of publications compared to prostate and uterine cancers.
  • Luteolin can inhibit oxidative stress, activation of microglia and astrocytes.
  • In mono-acyl derivatives of luteolin, the benzylation of the hydroxy groups at 7-, 3′- and 4′- positions can enhance the oral bioavailability of this compound.
  • Luteolin modulate apoptosis, autophagy, angiogenesis, cell cycle progression, metastasis, and epithelial–mesenchymal transition in cancer cells.
  • Luteolin induce apoptosis in cancer cells via regulation of extrinsic and intrinsic apoptotic pathways.

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© 2023 by the NMB. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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History

  • Receive Date: 25 June 2023
  • Revise Date: 08 August 2023
  • Accept Date: 09 August 2023

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